Map Editor is a tile-based map maker primarily targeted for 2D games. It's made with Tkinter in Python and is meant to be language and library agnostic. It currently supports tiles up to 256 px. on rectangular maps of arbitrary size.
Pygame SGE An easy to use, universal 2-D game engine.
Fat x Fast This is a python puzzle / labyrinth game built upon pygame. Game supports
local multiplayer for 2 players. Most of the game maps are randomly generated
but custom maps can be created with tiled(http://www.mapeditor.org/).