A fan game of a 2d game calls GirlsFrontLine. One of the biggest game which is developed base on pygame.
This game is developed using an entirely new game engine base on pygame called Zero2. The goal of Zero2 is to provide an easier solution for a visual novel system other than Renpy. The zero2 engine also provides a well-designed battlefield system. The developer can be able to customize their own battlefield system very easily. The development is still in processing, and probably will be released in 5 months.